RNA Details
Disease Name
chronic kidney disease
Tissue
kidney
RNA Symbol
mir-4516
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
NA
Target
SIAH3
Pathway
NA
PubMed ID
Title
Melatonin Treatment Improves Renal Fibrosis via miR-4516/SIAH3/PINK1 Axis
Year
2021
Function
"MiR-4516 is downregulated and its target SIAH3, an E3 ubiquitin protein ligase that reduces PINK1 accumulation to damaged mitochondria, is upregulated in the renal cortex of chronic kidney disease ."